منابع مشابه
GATA-3 Maintains the Differentiation of the Luminal Cell Fate in the Mammary Gland
The GATA family of transcription factors plays fundamental roles in cell-fate specification. However, it is unclear if these genes are necessary for the maintenance of cellular differentiation after development. We identified GATA-3 as the most highly enriched transcription factor in the mammary epithelium of pubertal mice. GATA-3 was found in the luminal cells of mammary ducts and the body cel...
متن کاملCompetition and collaboration: GATA-3, PU.1, and Notch signaling in early T-cell fate determination.
T-cell precursors remain developmentally plastic for multiple cell generations after entering the thymus, preserving access to developmental alternatives of macrophage, dendritic-cell, and even mast-cell fates. The underlying regulatory basis of this plasticity is that early T-cell differentiation depends on transcription factors which can also promote alternative developmental programs. Interf...
متن کاملProgenitor Cell Fate Decisions in Mammary Tumorigenesis
Crowe DL, Wan R, Baloue K. 2011. Coordinate activation of the NBS1 gene regulates estradiol mediated protection from double strand DNA breaks. Era of Hope Breast Cancer Research Meeting. Orlando, FL Published manuscripts: Wan R, Crowe DL. 2012. Haploinsufficiency of the Nijmegen breakage syndrome 1 gene increases mammary tumor latency and metastasis. Int J Oncol 41:345-352 Wan R, Wu J, Baloue K...
متن کاملMicroRNA-205 signaling regulates mammary stem cell fate and tumorigenesis.
Dysregulation of epigenetic controls is associated with tumorigenesis in response to microenvironmental stimuli; however, the regulatory pathways involved in epigenetic dysfunction are largely unclear. We have determined that a critical epigenetic regulator, microRNA-205 (miR-205), is repressed by the ligand jagged1, which is secreted from the tumor stroma to promote a cancer-associated stem ce...
متن کاملRegulation of Mammary Luminal Cell Fate and Tumorigenesis by p38α
Mammary stem and progenitor cells are essential for mammary gland homeostasis and are also candidates for cells of origin of mammary tumors. Here, we have investigated the function of the protein kinase p38α in the mammary gland using mice that delete this protein in the luminal epithelial cells. We show that p38α regulates the fate of luminal progenitor cells through modulation of the transcri...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Breast Cancer Research
سال: 2007
ISSN: 1465-542X
DOI: 10.1186/bcr1661